Effects of Landiolol, an Ultra-Short-Acting .BETA.1-Selective Blocker, on Electrical Storm Refractory to Class III Antiarrhythmic Drugs
Why the study?
Does landiolol inhibit electrical storm in patients refractory to class III antiarrhythmic drugs?
Population
42 consecutive patients who developed electrical storm for which intravenous class III antiarrhythmic drugs…
Design
Cohort
Follow-up
until hospital discharge
Authors
Discussion
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Member takes
Implication
May support landiolol for refractory electrical storm; hypothesis-generating and requires randomized confirmation.
Structured PICO
Does landiolol inhibit electrical storm in patients refractory to class III antiarrhythmic drugs?
P
Population
42 consecutive patients who developed electrical storm (ES) for which intravenous class III antiarrhythmic drugs (such as amiodarone and nifekalant) were ineffective.
I
Intervention
Landiolol administered intravenously with an initial dose of 2.5 microg/kg/min, doubled if ineffective, up to a maximum dose of 80 microg/kg/min.
O
Outcome
Inhibition of electrical stormhard clinical
Intravenous landiolol is an effective and potentially life-saving treatment for electrical storm refractory to class III antiarrhythmic drugs.
Cite This Study
Miwa et al. (2010) studied this question.