Why the study?
Does nifedipine monotherapy affect mortality and adverse cardiovascular outcomes in patients with hypertension and stable angina pectoris?
Does nifedipine monotherapy affect mortality and adverse cardiovascular outcomes in patients with hypertension and stable angina pectoris?
Nifedipine monotherapy may increase the risk of mortality and adverse cardiovascular outcomes in patients with stable angina pectoris, depending on the formulation used.
Supports caution with nifedipine monotherapy in stable angina; challenges prior safety assumptions and extends formulation-specific evidence versus hypertension.
UNLABELLED: META-ANALYSIS: A meta-analysis of published randomized control trials of nifedipine in hypertension and stable angina pectoris was performed. RESULTS: The results suggest a formulation-dependent increased risk of mortality and adverse cardiovascular outcomes for monotherapy use in patients with stable angina pectoris. No increased risk was seen in the hypertension studies.
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Stason et al. (1996) studied this question.
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