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June 14, 2021Frontiers in ImmunologyOpen Access

Expression of ACE2, Soluble ACE2, Angiotensin I, Angiotensin II and Angiotensin-(1-7) Is Modulated in COVID-19 Patients

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Authors

IOIkram Omar OsmanCMCléa MelenottePBPhilippe Brouqui

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Overview

Observational study reveals dysregulated ACE2 expression and elevated angiotensin II in COVID-19 patients, suggesting impaired blood pressure regulation contributes to disease severity.

Key Points

  • To investigate whether SARS-CoV-2 infection alters ACE2 expression and plasma concentrations of angiotensin peptides in COVID-19 patients.
  • Assessed ACE2 mRNA and membrane protein expression in circulating blood cells and monocytes from COVID-19 patients and healthy controls.
  • Quantified plasma concentrations of soluble ACE2 (sACE2), angiotensin I, angiotensin II, and angiotensin-(1-7) across healthy controls, short viral shedders, and prolonged viral shedders.
  • Circulating blood cells and monocytes from COVID-19 patients exhibited decreased ACE2 mRNA and membrane ACE2 protein expression compared to healthy volunteers.
  • Prolonged viral shedders showed significantly decreased plasma sACE2 alongside elevated concentrations of angiotensin I and angiotensin II compared to healthy controls.
  • Plasma concentrations of angiotensin-(1-7) remained stable in prolonged viral shedders, proving insufficient to counteract the harmful accumulation of angiotensin II.

Cite This Study

Osman et al. (2021) studied this question.

synapsesocial.com/papers/6a717e9cb5c1fe5ca9dfd9aehttps://doi.org/10.3389/fimmu.2021.625732
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