September 1, 1991Cardiovascular Research

Atrial compliance determines the nature of passive atrial stretch and plasma atrial natriuretic factor in the conscious dog

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Structured PICO

Population

Awake mongrel dogs (n=6 instrumented for left atrial appendage pressure and diameter; n=4 instrumented for left and right atrial appendage pressures and diameters)

Intervention

Acute graded haemorrhage (30 ml/kg) to reduce atrial stretch, and volume loading with 1000 ml saline to increase atrial stretch

Comparator

Baseline/control state

Outcome

Relationship between atrial stretch (pressure, diameter, wall stress) and plasma atrial natriuretic factor (ANF)surrogate

Atrial stretch and the release of atrial natriuretic factor are non-linearly related, with significant ANF release occurring only at very high atrial appendage wall stresses.

Discussion

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Implication

Cautions against clinical extrapolation from animal volume models; leaves open human translation of atrial stretch-ANF dynamics.

Cite This Study

Stewart et al. (1991) studied this question.

synapsesocial.com/papers/6a7181455d37378ac1dea461 https://doi.org/10.1093/cvr/25.9.784

View Full Paper

Ask AI

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Atrial compliance determines the nature of passive atrial stretch and plasma atrial natriuretic factor in the conscious dog

Structured PICO

Discussion

Implication

Cite This Study

Atrial compliance determines the nature of passive atrial stretch and plasma atrial natriuretic factor in the conscious dog

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider