Why the study?
Do total tricyclic antidepressant plasma levels correlate with major adverse effects and electrocardiographic findings in patients with TAD overdose?
Population
40 patients ingesting tricyclic antidepressant (TAD) overdoses
Design
Cohort
Authors
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Associates higher TAD levels with death, arrest, and QRS widening in overdose; supports correlation but leaves open whether levels should guide care.
Do total tricyclic antidepressant plasma levels correlate with major adverse effects and electrocardiographic findings in patients with TAD overdose?
Total tricyclic antidepressant plasma levels correlate well with the severity of biologic responses, including major adverse clinical and electrocardiographic effects following overdose.
Petit et al. (1977) studied this question.
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