Key result
A terminal 40 ms QRS axis ≥ 135 degrees was significantly associated with an increased likelihood of major toxicity in tricyclic antidepressant overdose (OR 2.73, p<0.05).
Why the study?
What demographic and electrocardiographic factors are associated with severe toxicity in patients with pure tricyclic antidepressant overdose?
Population
106 hospitalized patients with pure tricyclic antidepressant overdose
Design
Cohort
Authors
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May refine ECG risk stratification in TCA overdose; extends prior associations but leaves open prospective validation.
Cohort (n=106)
What demographic and electrocardiographic factors are associated with severe toxicity in patients with pure tricyclic antidepressant overdose?
Odds Ratio: 2.73
p-value: p=<0.05
Specific electrocardiographic parameters, including QRS interval ≥100 ms, QRS axis >90 degrees, and QTc >480 ms, are strongly associated with severe clinical toxicity in patients with tricyclic antidepressant overdose.
Caravati et al. (1991) conducted a cohort in Tricyclic antidepressant overdose (n=106). Terminal 40 ms QRS axis ≥ 135 degrees vs. Terminal 40 ms QRS axis < 135 degrees was evaluated on Major toxicity (seizures, endotracheal intubation, coma, arrhythmias requiring treatment, hypotension, or death) (OR 2.73, p=<0.05). A terminal 40 ms QRS axis ≥ 135 degrees was significantly associated with an increased likelihood of major toxicity in tricyclic antidepressant overdose (OR 2.73, p<0.05).
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