Key result
In severe tricyclic antidepressant toxicity, ECG conduction abnormalities vary widely in resolution time and are significantly more abnormal in patients who develop seizures or arrhythmias.
Population
36 patients who presented with an acute ingestion of a tricyclic antidepressant, who had at least three…
Design
Cohort
Follow-up
until discharge
Authors
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Variable ECG resolution in TCA toxicity cautions against fixed monitoring protocols; leaves open prospective validation of seizure-arrhythmia associations.
Cohort (n=36)
Yes
In severe tricyclic antidepressant toxicity, ECG conduction abnormalities vary widely in resolution time, sometimes remaining persistently abnormal despite clinical improvement, and are more pronounced in patients developing seizures or arrhythmias.
Liebelt et al. (1997) conducted a cohort in Acute tricyclic antidepressant poisoning (n=36). Acute tricyclic antidepressant poisoning vs. Patients without complications was evaluated on Changes over time of the QRS interval and terminal 40-msec QRS frontal axis (T40-ms). In severe tricyclic antidepressant toxicity, ECG conduction abnormalities vary widely in resolution time and are significantly more abnormal in patients who develop seizures or arrhythmias.
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