Key result
The median time to QRS resolution (<100 msec) after severe tricyclic antidepressant intoxication was 19.3 hours, and sodium bicarbonate did not significantly reduce this duration.
Why the study?
Does sodium bicarbonate reduce the duration of QRS widening in patients with severe tricyclic antidepressant intoxication?
Population
22 consecutive patients referred to a regional poison center after tricyclic antidepressant ingestion…
Comparison
Sodium bicarbonate (n=10) vs No sodium bicarbonate (n=12)
Design
Cohort
Follow-up
Until QRS interval was less than 100 msec (up to 78 hours)
Authors
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Sodium bicarbonate was not associated with shorter QRS resolution in severe TCA overdose; should not yet change practice and warrants randomized confirmation.
Cohort (n=22)
No
Does sodium bicarbonate reduce the duration of QRS widening in patients with severe tricyclic antidepressant intoxication?
QRS prolongation after severe tricyclic antidepressant ingestion typically lasts 12-18 hours but can persist up to 3 days, and its duration may not be reduced by sodium bicarbonate administration.
Michael W. Shannon (1992) conducted a cohort in Severe tricyclic antidepressant intoxication (n=22). Sodium bicarbonate vs. No sodium bicarbonate was evaluated on Duration of QRS widening. The median time to QRS resolution (<100 msec) after severe tricyclic antidepressant intoxication was 19.3 hours, and sodium bicarbonate did not significantly reduce this duration.
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