Key result
Red blood cell tricyclic antidepressant levels correlate strongly with admission QRS duration.
Why the study?
The relationship between tricyclic antidepressant levels in red blood cells and plasma and their association with cardiotoxicity in acute overdose was studied.
Population
15 patients with acute tricyclic antidepressant overdose
Comparison
Tricyclic antidepressant parent compounds and metabolites in red blood cells vs plasma
Design
Prospective observational study
Follow-up
6 to 10 hours
Authors
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TCA levels in plasma and RBC associated with ECG toxicity in overdose; leaves open added value of RBC measurement for risk stratification.
Observational (n=15)
Effect estimate: r = 0.77
p-value: p=<0.01
In acute tricyclic antidepressant overdose, red blood cell metabolite levels strongly correlate with QRS prolongation, serving as a marker for impaired intraventricular conduction.
Amitai et al. (1993) conducted an observational in Acute tricyclic antidepressant overdose (n=15). Tricyclic antidepressant levels in red blood cells and plasma was evaluated on Correlation of tricyclic antidepressant levels with ECG indexes of toxicity (QRS duration) (r = 0.77, p=<0.01). Red blood cell levels of tricyclic antidepressant metabolites were significantly correlated with QRS duration at admission (r = 0.77, p < 0.01), serving as markers for impaired conduction.
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