Population
Murine Kir2.1 potassium channel
Design
Preclinical
Authors
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Extends Kir-Kv pore homology in animal models; leaves open relevance to human cardiac channel function or therapies.
The topology of the Kir pore is similar to Kv channels, with selectivity potentially conferred by aromatic residues and backbone carbonyl groups.
Dart et al. (1998) studied this question.
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