Population
Kir2.1 channels (wild-type and mutants including S165L, T141A, D172N)
Comparison
Mutation of specific residues and exposure to… vs Wild-type Kir2.1 channels
Design
Preclinical
Authors
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Identifies candidate residues for cation block in Kir2.1; leaves open relevance to native channel function or human disease.
Thr141 and Ser165 likely provide binding sites for monovalent blocking cations in wild-type Kir2.1 channels, located beyond the selectivity filter.
Thompson et al. (2000) studied this question.
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