Why the study?
Dose equivalence between chlorthalidone and hydrochlorothiazide remains unclear, and their metabolic adverse effects may be attenuated by co-administering amiloride.
Does the combination of chlorthalidone or hydrochlorothiazide with amiloride in different doses improve blood pressure reduction in patients with primary hypertension?
Does the combination of chlorthalidone or hydrochlorothiazide with amiloride in different doses improve blood pressure reduction in patients with primary hypertension?
This protocol describes a planned 2x2 factorial RCT to compare the blood pressure lowering efficacy and safety of chlorthalidone versus hydrochlorothiazide in combination with different doses of amiloride in patients with primary hypertension.
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Resolves chlorthalidone-hydrochlorothiazide dose equivalence with amiloride; extends RCT evidence on metabolic safety in hypertension.
Martins et al. (2019) studied this question.
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