Why the study?
Does hydrochlorothiazide/amiloride improve anti-hypertensive and biochemical properties compared to chlorthalidone in ambulatory patients with mild to moderate hypertension?
Does hydrochlorothiazide/amiloride improve anti-hypertensive and biochemical properties compared to chlorthalidone in ambulatory patients with mild to moderate hypertension?
Hydrochlorothiazide/amiloride preserves plasma potassium better than chlorthalidone in patients with mild to moderate hypertension, while providing similar antihypertensive efficacy.
May favor HCTZ/amiloride to limit hypokalemia risk in mild hypertension; hypothesis-generating and requires randomized confirmation.
In an open two-period crossover study hydrochlorothiazide/amiloride and chlorthalidone were compared with regard to their anti-hypertensive and biochemical properties in ambulatory patients with mild to moderate hypertension. Twenty-five out of twenty-six patients completed the study. In the chlorthalidone group plasma potassium was consistently lower than in the hydrochlorothiazide/amiloride group, the difference achieved significance at 8 and 12 weeks after the start of treatment. With regard to the hypertension and other parameters no statistically significant differences were found.
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F van Soeren (1980) studied this question.
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