Key result
Chlorthalidone and hydrochlorothiazide, combined with amiloride at 10 mg or 20 mg, will be compared for blood pressure-lowering efficacy in a planned 12-week factorial randomized controlled trial.
Why the study?
Equivalent doses of chlorthalidone and hydrochlorothiazide remain unclear, and concerns persist regarding adverse metabolic effects that might be mitigated by co-administering amiloride.
Does the combination of chlorthalidone or hydrochlorothiazide with amiloride at different doses reduce blood pressure in patients with primary hypertension?
Population
84 planned patients with primary hypertension
Comparison
Chlorthalidone 25 mg/day or hydrochlorothiazide 50 mg/day plus amiloride 10 or 20 mg/day
Design
Factorial (2 × 2) randomized double-blind trial protocol
Follow-up
12 weeks
Authors
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Planned RCT will deliver direct comparative data on amiloride dosing with thiazides; extends evidence base for hypertension diuretic regimens.
RCT (n=84)
Double-blind
Factorial (2x2)
No
Does the combination of chlorthalidone or hydrochlorothiazide with amiloride at different doses reduce blood pressure in patients with primary hypertension?
This protocol outlines a factorial RCT to evaluate the blood pressure lowering efficacy and safety of chlorthalidone versus hydrochlorothiazide combined with different doses of amiloride in primary hypertension.
Martins et al. (2019) conducted an RCT in Primary hypertension (n=84). Chlorthalidone or Hydrochlorothiazide combined with Amiloride vs. Active comparators (factorial design) was evaluated on Mean change from baseline in 24-h systolic and diastolic blood pressure measured by ambulatory blood pressure monitoring (ABPM). Chlorthalidone and hydrochlorothiazide, combined with amiloride at 10 mg or 20 mg, will be compared for blood pressure-lowering efficacy in a planned 12-week factorial randomized controlled trial.
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