Why the study?
MitraClip is approved for functional mitral regurgitation but recurrence occurs in over one third of patients, potentially caused by device-induced mechanical effects.
Does simulated MitraClip alter leaflet stress and myocardial strain in finite element models of functional mitral regurgitation?
Population
Finite element models based on MRI of 5 sheep with FMR-CAD
Comparison
Simulated MitraClip vs baseline models, including a 20% increase in LV volume
Design
Finite element modeling simulation study
Authors
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May implicate device-induced stress in MR recurrence; leaves open need for clinical validation in FMR-CAD.
Does simulated MitraClip alter leaflet stress and myocardial strain in finite element models of functional mitral regurgitation?
Simulated MitraClip in FMR-CAD models increases mitral leaflet stress and radial strain in the LV sub-valvular myocardium, which may contribute to MR recurrence, especially with LV enlargement.
Zhang et al. (2019) studied this question.
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