June 19, 2007European Journal of Clinical Investigation
Interaction between cytokines and sCD40L in patients with stable and unstable coronary syndromes
Population
596 subjects including 201 patients with stable coronary artery disease, 109 patients with acute myocardial…
Design
Cross-sectional
Authors
Discussion
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Implication
sCD40L elevation in AMI may reflect diabetes and smoking rather than acute inflammation; leaves open its biomarker utility pending prospective studies.
Key Points
- Investigate the relationship between circulating sCD40L, proinflammatory cytokines, and soluble adhesion molecules across healthy subjects and patients with stable or acute coronary syndromes.
- Enrolled 596 subjects: 201 patients with stable CAD, 109 patients with acute myocardial infarction (AMI), and 286 healthy controls.
- Measured circulating levels of sCD40L, IL-6, sVCAM-1, and sICAM-1 via enzyme-linked immunosorbent assay (ELISA).
- Levels of sCD40L and IL-6 were significantly higher in AMI compared to CAD and controls (P < 0.01) and higher in CAD compared to controls (P < 0.01), while sICAM-1 and sVCAM-1 were higher in both CAD and AMI versus controls (P < 0.05).
- IL-6 was independently associated with sCD40L in healthy controls [beta (SE): 0.491 (0.096), P = 0.0001], but not in patients with CAD or AMI.
- Diabetes mellitus [beta (SE): 2.689 (1.082), P = 0.044 for CAD; beta (SE): 10.406 (3.215), P = 0.002 for AMI] and smoking [beta (SE): 3.470 (1.111), P = 0.002 for CAD; beta (SE): 9.694 (2.478), P = 0.0001 for AMI] were the only independent predictors of sCD40L.
Structured PICO
P
Population
596 subjects including 201 patients with stable coronary artery disease (CAD), 109 patients with acute myocardial infarction (AMI), and 286 healthy controls.
O
Outcome
Circulating levels of sCD40L, IL-6, sVCAM-1, and sICAM-1surrogate
sCD40L levels are elevated in CAD and AMI, and are independently associated with diabetes and smoking rather than inflammatory cytokines like IL-6 in these patients.
Cite This Study
Tousoulis et al. (2007) studied this question.