Why the study?
Do elevated plasma levels of sCD40L identify patients with acute coronary syndromes at heightened risk for recurrent cardiac events?
Population
390 patients with acute coronary syndromes
Comparison
Elevated plasma levels of sCD40L (above median) vs Plasma levels of sCD40L below median
Design
Case-control
Follow-up
10 months
Authors
Discussion
Loading...
Member takes
Implication
Elevated sCD40L was associated with higher recurrent risk in ACS; leaves open added value for risk stratification.
Structured PICO
Do elevated plasma levels of sCD40L identify patients with acute coronary syndromes at heightened risk for recurrent cardiac events?
P
Population
390 patients with acute coronary syndromes (nested case-control study within the OPUS-TIMI16 trial, 195 cases and 195 controls)
I
Intervention
Elevated plasma levels of sCD40L (above median)
C
Comparator
Plasma levels of sCD40L below median
O
Outcome
Composite of death, myocardial infarction (MI), or congestive heart failure (CHF) within 10 monthscomposite
Elevated plasma levels of sCD40L, especially when combined with troponin, independently identify patients with acute coronary syndromes at heightened risk for recurrent cardiovascular events.
Cite This Study
Varo et al. (2003) studied this question.