Key result
High levels of soluble CD40L independently predicted the risk of cardiovascular events in patients with asymptomatic low-grade carotid stenosis over a median follow-up of 8 years (P=0.003).
Why the study?
Do high levels of soluble CD40L predict the risk of cardiovascular events in patients with asymptomatic low-grade carotid stenosis?
Population
63 subjects with at least one major cardiovascular risk factor, comprising 42 patients with asymptomatic…
Design
Cohort
Follow-up
median 8 years
Authors
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May support soluble CD40L as a biomarker in asymptomatic low-grade carotid stenosis; hypothesis-generating and requires prospective validation before clinical use.
Cohort (n=63)
Do high levels of soluble CD40L predict the risk of cardiovascular events in patients with asymptomatic low-grade carotid stenosis?
p-value: p=0.003
Elevated soluble CD40L levels may serve as an independent biomarker for predicting future cardiovascular events in patients with asymptomatic low-grade carotid stenosis.
Novo et al. (2005) conducted a cohort in Asymptomatic low-grade carotid stenosis (n=63). High soluble CD40L (sCD40L) levels vs. Low sCD40L levels was evaluated on Cardiovascular events (p=0.003). High levels of soluble CD40L independently predicted the risk of cardiovascular events in patients with asymptomatic low-grade carotid stenosis over a median follow-up of 8 years (P=0.003).
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