Why the study?
Does L-NAME-induced hypertension alter cardiovascular neural reflexes in mice?
Population
Mice (n=17 total; 7 treated with L-NAME, 10 vehicle-treated)
Comparison
Nomega-nitro-L-arginine-methyl ester 400… vs Vehicle treatment
Design
Preclinical
Follow-up
7 days
Authors
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Differential reflex changes in L-NAME hypertensive mice; leaves open translation to human hypertension.
Does L-NAME-induced hypertension alter cardiovascular neural reflexes in mice?
Chronic inhibition of nitric oxide synthesis in mice induces hypertension, enhances baroreflex sensitivity, and attenuates the Bezold-Jarisch and chemoreflexes.
Peotta et al. (2001) studied this question.
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