In spontaneously hypertensive rats, blood pressure and heart weight may be independently controlled by different genetic mechanisms, with a gene close to the ANF locus on chromosome 5 contributing to hypertension.
Supports separate genetic control of blood pressure and heart weight in hypertensive rats; hypothesis-generating for ANF-linked loci in human hypertension.
Genetic factors may be involved in both essential hypertension and cardiac hypertrophy. To identify genes contributing to elevated for blood pressure and cardiac hypertrophy in the spontaneously hypertensive rat (SHR), we performed a cosegregation analysis between blood pressure and heart weight and microsatellite markers for the candidate gene ANF on chromosome 5 in F2 animals obtained by mating SHR with Wistar-Kyoto (WKY) rats. We found evidence for a quantitative trait locus (QTL) determining mean blood pressure on chromosome 5 between atrial natriuretic factor (ANF) and MITR-3893 loci. No evidence for a QTL influencing heart weight was found. We propose that in SHR, blood pressure and heart weight may be independently controlled by different genetic mechanisms and that a gene close to ANF locus on chromosome 5 contributes towards hypertension in these animals.
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Zhang et al. (1996) studied this question.
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