June 6, 1988FEBS Letters

Right atrial dilatation increases inositol‐(1,4,5)trisphosphate accumulation Implications for the control of atrial natriuretic peptide release

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Why the study?

Does right atrial stretching increase inositol-(1,4,5)trisphosphate accumulation in isolated rat hearts?

Population

Isolated perfused [3H]inositol-labelled rat hearts

Design

Preclinical

Follow-up

up to 20 minutes

Authors

RHRüdiger von HarsdorfUniversity of Maryland, Baltimore RLR. LangUniversity of Bern MFM FullertonNewcastle University

Discussion

Member takes

Implication

May link atrial stretch to ANP release via PI turnover in rats; leaves open human relevance.

Structured PICO

Does right atrial stretching increase inositol-(1,4,5)trisphosphate accumulation in isolated rat hearts?

Population

Isolated perfused [3H]inositol-labelled rat hearts

Intervention

Stretching the right atrium (right atrial dilatation)

Outcome

Accumulation of [3H]inositol-(1,4,5)trisphosphate and its degradation productssurrogate

Right atrial dilatation activates the phosphatidylinositol turnover pathway in rat myocardium, suggesting a mechanism for atrial natriuretic peptide release following atrial distention.

Cite This Study

Harsdorf et al. (1988) studied this question.

synapsesocial.com/papers/6a718df1a2d7cf2e39c2d1d4 https://doi.org/10.1016/0014-5793(88)81384-x

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Right atrial dilatation increases inositol‐(1,4,5)trisphosphate accumulation Implications for the control of atrial natriuretic peptide release

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Right atrial dilatation increases inositol‐(1,4,5)trisphosphate accumulation Implications for the control of atrial natriuretic peptide release

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider