Key result
In stroke-prone spontaneously hypertensive rats, norepinephrine stimulation significantly increased IP3, diacylglyceride, protein kinase C activity, and intracellular calcium compared to WKY rats.
Population
Isolated myocytes from stroke-prone spontaneously hypertensive rat heart and Wistar-Kyoto rats at 30-40…
Comparison
Norepinephrine stimulation vs Wistar-Kyoto (WKY) rats (normotensive control)
Design
Preclinical
Authors
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May implicate IP3-PKC signaling in hypertensive hypertrophy; hypothesis-generating in rodents, human relevance remains open.
The phosphatidylinositol-turnover pathway and diacylglyceride-protein kinase C pathway may play an important role in the development of cardiac hypertrophy in pressure-overloaded hearts.
Kawaguchi et al. (1993) studied Pressure-overloaded hypertrophic heart. Stroke-prone spontaneously hypertensive rat (SHRSP) model vs. Wistar-Kyoto (WKY) rats was evaluated on Phosphatidylinositol metabolism (accumulation of IP3 and diacylglyceride, protein kinase C activity, intracellular calcium concentration). In stroke-prone spontaneously hypertensive rats, norepinephrine stimulation significantly increased IP3, diacylglyceride, protein kinase C activity, and intracellular calcium compared to WKY rats.
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