Population
Human atrial appendages from patients with persistent atrial fibrillation and sinus rhythm, human…
Comparison
Synthetic peptide corresponding to the… vs Sinus rhythm; control/vehicle
Design
Preclinical
Authors
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Hypothesis-generating for atrial ECM glycoproteins in fibrosis; leaves open clinical translation pending validation.
Proteomic analysis of the human cardiac extracellular matrix reveals novel processed forms of decorin in atrial fibrillation that can regulate myostatin activity, highlighting a potential mechanism for modulating hypertrophy and fibrosis.
Barallobre‐Barreiro et al. (2016) studied this question.
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