Angioedema Induced by the Angiotensin II Blocker Losartan

Christopher G. Acker; Arthur Greenberg

doi:10.1056/nejm199512073332316

December 7, 1995New England Journal of MedicineOpen Access

Angioedema Induced by the Angiotensin II Blocker Losartan

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Key Points

Document and evaluate the occurrence of angioedema associated with the oral angiotensin II receptor antagonist losartan.
Clinical case evaluation documenting adverse reaction onset following losartan therapy.
Comparison of angiotensin II receptor blocker mechanisms with angiotensin-converting enzyme inhibitor pathways.
Losartan administration was observed to induce angioedema in a clinical setting.
The occurrence indicates that angioedema can develop with selective angiotensin II blockers despite differing mechanisms from ACE inhibitor-induced bradykinin accumulation.

Structured PICO

I

Intervention

Losartan

O

Outcome

Angioedemasafety

Losartan, an angiotensin II receptor blocker, may induce angioedema.

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Implication

Losartan may induce angioedema; this Level 5 report leaves open its true incidence and class effect.

Abstract

To the Editor: Losartan (Cozaar, Merck) is a new, orally effective blocker of the angiotensin II receptor. The currently available angiotensin-converting–enzyme (ACE) inhibitors block the degradati...

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Cite This Study

Acker et al. (1995) studied this question.

synapsesocial.com/papers/6a71934931a3df824329b422 https://doi.org/10.1056/nejm199512073332316

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Angioedema Induced by the Angiotensin II Blocker Losartan

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Angioedema Induced by the Angiotensin II Blocker Losartan

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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