Key result
In animal models of hypertension, losartan demonstrated equivalent efficacy to ACE inhibitors without the detrimental side effects attributed to kinin potentiation.
Why the study?
Does losartan have equivalent efficacy to ACE inhibitors in animal models of hypertension?
Population
Animal models of hypertension and its complications
Comparison
Losartan (angiotensin II receptor antagonist) vs ACE inhibitors
Design
Review
Authors
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Losartan may offer ACE inhibitor-like efficacy without kinin-related risks in hypertension; hypothesis-generating from animal models, human trials required.
Does losartan have equivalent efficacy to ACE inhibitors in animal models of hypertension?
Losartan demonstrates equivalent efficacy to ACE inhibitors in animal models of hypertension, suggesting it offers similar benefits without kinin-related side effects.
Siegl et al. (1995) conducted a review in Hypertension. Losartan vs. ACE inhibitors was evaluated. In animal models of hypertension, losartan demonstrated equivalent efficacy to ACE inhibitors without the detrimental side effects attributed to kinin potentiation.
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