Population
Preclinical animal models of experimental and genetic hypertension, renal disease, stroke-prone…
Comparison
Losartan (AT1 receptor antagonist) vs ACE inhibitors and renin inhibitors
Design
Review
Authors
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Preclinical support for losartan in hypertension and HF warrants clinical trials; leaves open translation to practice without randomized human data.
Preclinical evidence establishes losartan as a potent and specific AT1 receptor antagonist with therapeutic potential for chronic diseases such as hypertension and heart failure.
Timmermans et al. (1995) studied this question.
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