Why the study?
Do bis(arylalkyl)amines act as selective class III antiarrhythmic agents by prolonging the effective refractory period in isolated cardiac tissue?
Do bis(arylalkyl)amines act as selective class III antiarrhythmic agents by prolonging the effective refractory period in isolated cardiac tissue?
Compound 16, a bis(arylalkyl)amine with methanesulfonamido moieties, is a potent and selective class III antiarrhythmic agent that blocks cardiac potassium channels.
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Hypothesis-generating for bis(arylalkyl)amines as class III agents; leaves open clinical translation and safety.
A series of bis(arylalkyl)amines is described and their effects on prolonging effective refractory period in isolated cardiac tissue listed. Most compounds prolonged the cardiac action potential without significantly altering the maximum rate of depolarization and may be defined as selective class III antiarrhythmic agents. It was found that a particularly advantageous structural feature was to have a methanesulfonamido moiety on both of the aryl rings. Thus, compound 16 [1-(4-methanesulfonamidophenoxy)2-[N-(4-methanesulfonamidophene thyl)-N- methylamine]ethane] was selected for further investigations. The compound is highly potent and selective class III agent which acts by blockade of cardiac potassium channels.
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Cross et al. (1990) studied this question.
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