Why the study?
Does recombinant human erythropoietin elevate blood pressure and modulate tissue renin-angiotensin systems in normal Wistar rats?
Population
40 normal Wistar rats (4 groups of 10)
Comparison
Recombinant human erythropoietin, enalapril, or… vs Vehicle
Design
Preclinical
Authors
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rhEPO may activate tissue RAS in rats; leaves open relevance to human EPO-associated hypertension.
Does recombinant human erythropoietin elevate blood pressure and modulate tissue renin-angiotensin systems in normal Wistar rats?
Recombinant human erythropoietin modulates specific tissue renin-angiotensin systems, which may contribute to blood pressure elevation that can be prevented by ACE inhibitors.
Eggena et al. (1991) studied this question.
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