What question did this study set out to answer?

To investigate the effects of recombinant human erythropoietin on blood pressure and the endothelin-1/endothelin B receptor pathway in healthy rodents and endothelin receptor knockout mice.

April 28, 2008American Journal of HypertensionOpen Access

Effect of Erythropoietin on Blood Pressure and on the Vascular Endothelial ET-1/ETB Receptor System

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To investigate the effects of recombinant human erythropoietin on blood pressure and the endothelin-1/endothelin B receptor pathway in healthy rodents and endothelin receptor knockout mice.
Administered vehicle or recombinant human erythropoietin (100 U/kg subcutaneously three times weekly) to normal rats, heterozygous ET(B)R knockout mice, ET(A)R knockout mice, and wild-type controls.
Quantified vascular and renal cortex ET(B)R mRNA expression and endothelial receptor density via immunohistochemistry in rats.
Measured blood pressure and thoracic aorta endothelin-1 concentrations in mice.
Erythropoietin increased hematocrit in all treated animals without altering blood pressure in normal rats.
Normal rats treated with erythropoietin showed significantly increased ET(B)R mRNA expression in the renal cortex and vasculature, alongside higher endothelial receptor density.
In ET(B)R-deficient mice, erythropoietin elevated blood pressure in association with increased endothelin-1 concentrations in the thoracic aorta.

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Implication

Experimental study reveals that erythropoietin induces hypertension only during endothelin B receptor deficiency in rodents, suggesting a protective role for endothelial receptors.

Cite This Study

Rodrigue et al. (2008) studied this question.

synapsesocial.com/papers/6a717a2c5d37378ac1de9fe1 https://doi.org/10.1038/ajh.2008.37

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Implication

Experimental study reveals that erythropoietin induces hypertension only during endothelin B receptor deficiency in rodents, suggesting a protective role for endothelial receptors.

Effect of Erythropoietin on Blood Pressure and on the Vascular Endothelial ET-1/ETB Receptor System

Key Points

Discussion

Implication

Cite This Study

Effect of Erythropoietin on Blood Pressure and on the Vascular Endothelial ET-1/ETB Receptor System

Key Points

Discussion

Implication

Cite This Study

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