Why the study?
Does evening dosing of ACE inhibitors reduce dry cough in hypertensive patients compared to morning dosing?
Population
Hypertensive patients and hypertensive rats
Comparison
Evening (inactive period) dosing of ACE inhibitors vs Morning dosing of ACE inhibitors
Design
Review
Authors
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May support evening ACE inhibitor dosing to lessen cough; leaves open need for RCTs before practice change.
Does evening dosing of ACE inhibitors reduce dry cough in hypertensive patients compared to morning dosing?
Evening dosing of ACE inhibitors may be an effective strategy to reduce the incidence and severity of dry cough in hypertensive patients.
Ohmori et al. (2005) studied this question.
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