Why the study?
Does adding a prasugrel loading dose to a clopidogrel loading dose reduce platelet reactivity compared with a prasugrel loading dose alone in ACS patients undergoing PCI?
Population
282 patients with acute coronary syndrome undergoing percutaneous coronary intervention
Comparison
Clopidogrel 600 mg loading dose followed 24… vs Placebo followed by prasugrel 60 mg loading dose…
Design
RCT, randomized to 3 LD strategies, double-blind, double-dummy
Follow-up
72 hours
Authors
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No incremental platelet inhibition from prior clopidogrel with prasugrel; confirms lack of additive benefit for dual loading in ACS PCI.
Does adding a prasugrel loading dose to a clopidogrel loading dose reduce platelet reactivity compared with a prasugrel loading dose alone in ACS patients undergoing PCI?
Adding a prasugrel loading dose to a prior clopidogrel loading dose does not significantly alter platelet reactivity compared to a prasugrel loading dose alone in ACS patients undergoing PCI.
Diodati et al. (2013) studied this question.
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