Renal Denervation for the Treatment of Hypertension: Making a New Start, Getting It Right
Why the study?
Does renal denervation reduce systolic blood pressure compared to a sham procedure in patients with hypertension?
Population
Hypertensive patients with systolic blood pressure between 150 mm Hg and 180 mm Hg off previous treatment
Comparison
Renal denervation (proposed) vs Sham procedure (proposed)
Design
Guideline
Authors
Discussion
Loading...
Member takes
Implication
Inconsistent renal denervation results leave its hypertension role open; further rigorous trials needed before practice change.
Structured PICO
Does renal denervation reduce systolic blood pressure compared to a sham procedure in patients with hypertension?
P
Population
Hypertensive patients with systolic blood pressure between 150 mm Hg and 180 mm Hg off previous treatment (proposed trial population)
I
Intervention
Renal denervation (proposed)
C
Comparator
Sham procedure (proposed)
O
Outcome
Difference in achieved systolic blood pressure between the intervention and control groups, measured by ambulatory blood pressure monitoring (ABPM) after 2 months (proposed)surrogate
This consensus statement proposes that future studies of renal denervation for hypertension should adopt rigorous, sham-controlled, randomized designs similar to those used for antihypertensive drug trials.
Cite This Study
Weber et al. (2015) studied this question.