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June 9, 2014European Journal of Preventive CardiologyOpen Access

The editorial discusses that the Symplicity HTN-3 trial showed no statistically significant difference in the effect of renal denervation on office blood pressure at 6 months follow-up compared to a sham procedure.

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Why the study?

Does catheter-based renal denervation reduce office blood pressure in patients with resistant hypertension compared to a sham procedure?

Population

Patients with resistant hypertension (discussing the Symplicity HTN-3 trial population)

Comparison

Catheter-based renal denervation vs Sham procedure

Design

Editorial

Authors

PBPeter J. BlankestijnMAMarco AlingsMVMichiel Voskuil

Discussion

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Member takes

Overview

Neutral Symplicity HTN-3 result advises against routine renal denervation adoption; leaves open optimization of technique, devices, and patient selection.

Structured PICO

Does catheter-based renal denervation reduce office blood pressure in patients with resistant hypertension compared to a sham procedure?

P
Population
Patients with resistant hypertension (discussing the Symplicity HTN-3 trial population)
I
Intervention
Catheter-based renal denervation (using the single polar Medtronic Symplicity device)
C
Comparator
Sham procedure (including cannulation of the femoral artery and an angiogram)
O
Outcome
Office blood pressure at 6 months follow-upsurrogate

Following the neutral results of Symplicity HTN-3, future research on renal denervation must address procedural adequacy, device differences, patient selection, and medication adherence.

Limitations

  • Interventionalists were well into the learning curve (average 3.3 procedures per operator)
  • No methods to directly measure or visualize the effects of the intervention itself
  • Medication use is a major and poorly controlled confounder

Cite This Study

Blankestijn et al. (2014) studied this question.

synapsesocial.com/papers/6a841b16c2c8a33f31f79777https://doi.org/10.1177/2047487314538859
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Also Consider

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