Key result
Renal denervation for resistant hypertension yielded lower blood pressure reductions in sham-controlled trials than initially expected, prompting reassessment of procedural efficacy and mechanisms.
Why the study?
Does renal denervation reduce blood pressure in patients with resistant hypertension?
Population
Patients with resistant hypertension
Comparison
Renal denervation vs Sham procedure or standard medical therapy
Design
Review
Authors
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Renal denervation should not change practice for resistant hypertension; leaves open refined techniques and patient selection in future trials.
Does renal denervation reduce blood pressure in patients with resistant hypertension?
This review highlights that the failure of SYMPLICITY HTN-3 may be due to inadequate denervation and patient selection, suggesting a potential future role for the procedure with improved techniques.
Iliescu et al. (2015) conducted a review in resistant hypertension. Renal denervation was evaluated. Renal denervation for resistant hypertension yielded lower blood pressure reductions in sham-controlled trials than initially expected, prompting reassessment of procedural efficacy and mechanisms.
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