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September 1, 2014Chinese Medical JournalOpen Access

Renal denervation: a new therapeutic approach for resistant hypertension

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Why the study?

Does renal denervation improve outcomes in patients with resistant hypertension?

Population

Patients with resistant hypertension and other diseases characterized by sympathetic overactivity

Design

Review

Authors

CLCao LongxingQFQiang FuZLZhiliang Li

Discussion

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Overview

Does not support routine use in resistant hypertension; leaves open efficacy pending further blinded RCTs.

Structured PICO

Does renal denervation improve outcomes in patients with resistant hypertension?

P
Population
Patients with resistant hypertension and other diseases characterized by sympathetic overactivity
I
Intervention
Renal denervation (catheter-based disruption of renal sympathetic efferent and afferent nerves through radiofrequency or ultrasound energy)

Renal denervation is a promising but currently controversial catheter-based therapy for resistant hypertension that requires further large-scale, blinded, randomized controlled trials to establish its efficacy.

Limitations

  • lack of long term efficacy and safety data
  • lack of predictors for the blood pressure lowering response and nonresponse to the procedure

Cite This Study

Longxing et al. (2014) studied this question.

synapsesocial.com/papers/6a7e7094299be60fdbb29bb7https://doi.org/10.1097/00029330-201409200-00020
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Catheter-Based Renal Sympathetic Denervation for Resistant Hypertension2011 · 745 citations
  2. 2Renal denervation for “resistant ventricular tachycardia”: a potential treatment option?2013 · 6 citations
  3. 3Renal Denervation in Moderate to Severe CKD2012 · 361 citations
  4. 4Renal Hemodynamics and Renal Function After Catheter-Based Renal Sympathetic Denervation in Patients With Resistant Hypertension2012 · 306 citations
  5. 5Effects of Renal Sympathetic Denervation on Blood Pressure, Sleep Apnea Course, and Glycemic Control in Patients With Resistant Hypertension and Sleep Apnea2011 · 462 citations