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June 1, 2013Expert Review of Cardiovascular Therapy

Renal denervation in treatment-resistant hypertension: the need for restraint and more and better evidence

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Key result

Adequately powered randomized clinical trials are urgently needed to establish the long-term safety, efficacy, and cardiovascular outcomes of renal denervation for treatment-resistant hypertension.

Population

Patients with treatment-resistant hypertension

Design

Editorial

Authors

APAlexandre PersuVascular MedicineJRJean RenkinRadiance Technologies (United States)KAKei AsayamaFukuoka Institute of Technology

Discussion

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Overview

Renal denervation should not enter routine practice for resistant hypertension; leaves open its long-term role pending definitive RCTs.

Structured PICO

P
Population
Patients with treatment-resistant hypertension
I
Intervention
Intravascular renal sympathetic nervous denervation

Widespread use of renal denervation for resistant hypertension should be restrained until adequately powered randomized clinical trials establish its long-term efficacy and safety.

Limitations

  • Most ongoing studies are small, industry-driven and purely observational

Cite This Study

Persu et al. (2013) conducted an editorial in treatment-resistant hypertension. Renal denervation was evaluated. Adequately powered randomized clinical trials are urgently needed to establish the long-term safety, efficacy, and cardiovascular outcomes of renal denervation for treatment-resistant hypertension.

synapsesocial.com/papers/6a77975d6789de8d0af74edahttps://doi.org/10.1586/erc.13.52
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Resistant Hypertension: Diagnosis, Evaluation, and Treatment2008 · 2,238 citations
  2. 2Renal denervation: time to open Pandora’s box2012 · 8 citations
  3. 3A Randomized Comparison of Pulmonary Vein Isolation With Versus Without Concomitant Renal Artery Denervation in Patients With Refractory Symptomatic Atrial Fibrillation and Resistant Hypertension2012 · 431 citations
  4. 4Improved Heart Rate Dynamics in Patients Undergoing Percutaneous Renal Denervation2012 · 17 citations
  5. 5Renal denervation: a potential new treatment modality for polycystic ovary syndrome?2011 · 143 citations