We have developed an efficient synthetic method for the production of substituted tetrahydropyrano[2, 3‐c]pyrazoles using ( E )‐2‐nitro‐1,3‐enynes, 1‐aryl‐3‐substituted pyrazolones and methyl vinyl ketone. The sequential, one‐pot reaction proceeded smoothly to give the desired products in high to excellent yields and stereoselectivities in the presence of a quinine‐derived squaramide organocatalyst.
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Wu et al. (2018) studied this question.
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