Why the study?
Does endothelial cell-specific PPARgamma disruption influence high fat diet-induced hypertension and the response to rosiglitazone in mice?
Population
8- to 12-week-old congenic PPARgamma (fl/fl)Cre- (wild type) and PPARgamma (fl/fl)T2T+ (PPARgamma E-null) mice
Comparison
2 months of salt-loading, or 3 months of high… vs Wild-type littermates undergoing the same…
Design
Preclinical
Follow-up
Up to 3 months
Authors
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Rosiglitazone effects may require endothelial PPARgamma under metabolic stress; leaves open translation to human hypertension.
Does endothelial cell-specific PPARgamma disruption influence high fat diet-induced hypertension and the response to rosiglitazone in mice?
Endothelial PPARgamma plays a crucial role in regulating blood pressure under metabolic stress and mediates the antihypertensive effects of rosiglitazone.
Nicol et al. (2005) studied this question.
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