Why the study?
Are glycosylated haemoglobin levels and diabetes mellitus duration associated with the severity of coronary artery disease in patients with acute myocardial infarction?
Are glycosylated haemoglobin levels and diabetes mellitus duration associated with the severity of coronary artery disease in patients with acute myocardial infarction?
Higher HbA1C levels and longer duration of diabetes mellitus are independently associated with increased angiographic severity of coronary artery disease in patients presenting with acute myocardial infarction.
HbA1c may mark CAD severity in diabetic AMI; hypothesis-generating and requires prospective trials before informing practice.
Diabetes mellitus (DM) is known to cause microvascular and possibly macrovascular complications. This study was performed to find the association between glycosylated haemoglobin (HbA1C) level and the severity of coronary artery disease. One hundred and ten consecutive patients admitted to hospital with acute myocardial infarction were studied. Seventy-eight patients (70.9%) had DM, 73 (93.58%) had HbA1C > 7%, 52 (47.3%) were hypertensive, 19 (17.3%) had a history of smoking and 37 (33.6%) had raised cholesterol. Coronary angiography was carried out in 87 (79.1%) patients and the severity of disease was assessed using the Gensini score. The mean Gensini score was 53.36+/-36.94 and the mean HbA1C was 8.4+/-2.39%. There was a significant association between Gensini score and DM (p=0.003) and between Gensini score and hypertension (p=0.018). HbA1C (r=0.427, p=0.001) and duration of DM (r=0.362, p=0.004) had a positive linear correlation with the Gensini score. Multiple regression analysis showed HbA1C to be an independent factor that influenced the Gensini score (p=0.021).
No takes yet. Share an insight, caveat, or question.
Saleem et al. (2008) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: