May 2, 2000Annals of Internal Medicine

Hyponatremia, Cerebral Edema, and Noncardiogenic Pulmonary Edema in Marathon Runners

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Why the study?

Does hypertonic saline (IV NaCl 514 mmol/L) improve outcomes in marathon runners with noncardiogenic pulmonary edema and hyponatremic encephalopathy?

Population

7 healthy marathon runners with a history of nonsteroidal anti-inflammatory drug use who collapsed after…

Design

Case_series

Follow-up

1 year

Authors

JAJuan Carlos Ayus JVJoseph Varón AAAllen I. Arieff

Discussion

Member takes

Overview

May support hypertonic saline for hyponatremic encephalopathy in marathon runners; hypothesis-generating and requires prospective confirmation.

Structured PICO

Does hypertonic saline (IV NaCl 514 mmol/L) improve outcomes in marathon runners with noncardiogenic pulmonary edema and hyponatremic encephalopathy?

Population

7 healthy marathon runners with a history of nonsteroidal anti-inflammatory drug use who collapsed after competing and were hospitalized with pulmonary edema.

Intervention

Intravenous NaCl, 514 mmol/L (hypertonic saline)

Outcome

Resolution of pulmonary and cerebral edema and survivalhard clinical

Noncardiogenic pulmonary edema in marathon runners can be a manifestation of hyponatremic encephalopathy and is successfully treated with hypertonic saline.

Cite This Study

Ayus et al. (2000) studied this question.

synapsesocial.com/papers/6a71a0995671bbf00bc2ed7c https://doi.org/10.7326/0003-4819-132-9-200005020-00005

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May 2, 2000Annals of Internal Medicine

Hyponatremia, Cerebral Edema, and Noncardiogenic Pulmonary Edema in Marathon Runners

View Full Paper

Ask AI

Bookmark

Why the study?

Does hypertonic saline (IV NaCl 514 mmol/L) improve outcomes in marathon runners with noncardiogenic pulmonary edema and hyponatremic encephalopathy?

Population

7 healthy marathon runners with a history of nonsteroidal anti-inflammatory drug use who collapsed after…

Design

Case_series

Follow-up

1 year

Authors

JAJuan Carlos Ayus JVJoseph Varón AAAllen I. Arieff

Discussion

Member takes

Overview

May support hypertonic saline for hyponatremic encephalopathy in marathon runners; hypothesis-generating and requires prospective confirmation.

Structured PICO

Does hypertonic saline (IV NaCl 514 mmol/L) improve outcomes in marathon runners with noncardiogenic pulmonary edema and hyponatremic encephalopathy?

Population

7 healthy marathon runners with a history of nonsteroidal anti-inflammatory drug use who collapsed after competing and were hospitalized with pulmonary edema.

Intervention

Intravenous NaCl, 514 mmol/L (hypertonic saline)

Outcome

Resolution of pulmonary and cerebral edema and survivalhard clinical

Noncardiogenic pulmonary edema in marathon runners can be a manifestation of hyponatremic encephalopathy and is successfully treated with hypertonic saline.

Cite This Study

Ayus et al. (2000) studied this question.

synapsesocial.com/papers/6a71a0995671bbf00bc2ed7c https://doi.org/10.7326/0003-4819-132-9-200005020-00005

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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