July 1, 1998Diabetic Medicine
Glycated haemoglobin and cardiovascular risk factors in Chinese subjects with normal glucose tolerance
Why the study?
Is higher HbA1c associated with worse cardiovascular risk factors in subjects with normal glucose tolerance?
Population
1280 Chinese subjects with normal glucose tolerance (785 men, 495 women)
Comparison
Higher HbA1c levels (evaluated by tertiles) vs Lower HbA1c levels (lower tertiles)
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Even within normal glucose tolerance, higher HbA1c is associated with a worse cardiovascular risk factor profile, suggesting cardiovascular risk begins before conventionally-defined glucose intolerance.
Structured PICO
Is higher HbA1c associated with worse cardiovascular risk factors in subjects with normal glucose tolerance?
P
Population
1280 Chinese subjects with normal glucose tolerance (785 men, 495 women)
I
Intervention
Higher HbA1c levels (evaluated by tertiles)
C
Comparator
Lower HbA1c levels (lower tertiles)
O
Outcome
Relationship between HbA1c and cardiovascular risk factors (blood pressure, waist-hip ratio, glucose, insulin, lipids, urate)surrogate
Even within normal glucose tolerance, higher HbA1c is associated with a worse cardiovascular risk factor profile, suggesting cardiovascular risk begins before conventionally-defined glucose intolerance.
Cite This Study
Ko et al. (1998) studied this question.