Key result
In participants with normal glucose tolerance, the highest quartile of HbA1c was associated with a 68% increased odds of elevated carotid intima-media thickness compared to the lowest quartile.
Why the study?
Is HbA1c associated with carotid intima-media thickness in subjects with normal glucose tolerance?
Population
1,627 participants with normal glucose tolerance, aged 40 years and above, recruited from a community in…
Design
Cross-sectional
Authors
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May flag higher subclinical atherosclerosis risk via HbA1c even in normoglycemia; leaves open prospective validation before clinical use.
Cross-Sectional (n=1,627)
No
Is HbA1c associated with carotid intima-media thickness in subjects with normal glucose tolerance?
Odds Ratio: 1.68
p-value: p=0.016
In individuals with normal glucose tolerance, HbA1c is significantly associated with increased carotid intima-media thickness independent of fasting and postchallenge glucose, suggesting it may be a more informative marker of cardiovascular risk.
Huang et al. (2011) conducted a cross-sectional in Normal glucose tolerance (n=1,627). Highest quartile of HbA1c vs. Lowest quartile of HbA1c was evaluated on Elevated carotid intima-media thickness (≥ 0.70 mm) (OR 1.68, p=0.016). In participants with normal glucose tolerance, the highest quartile of HbA1c was associated with a 68% increased odds of elevated carotid intima-media thickness compared to the lowest quartile.
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