Key result
In individuals with normal glucose tolerance, A1C was independently associated with carotid intima-media thickness and explained 4.4% of its variation, whereas 1-hour glucose was not informative.
Population
1,219 nondiabetic individuals from the Metabolic Syndrome Berlin Potsdam study, including 558 with normal…
Design
Cross-sectional
Authors
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A1C links to carotid IMT in normoglycemia; hypothesis-generating for early glycemic role in atherosclerosis and requires prospective confirmation.
Cross-Sectional (n=1,219)
Effect estimate: Standardized β 0.139
p-value: p=0.002
A1C is the most informative glycemic marker associated with carotid intima-media thickness in individuals with normal glucose tolerance, suggesting glycemic control has pathophysiological relevance in atherosclerosis development even before diabetes onset.
Bobbert et al. (2009) conducted a cross-sectional in Normal glucose tolerance (n=1,219). A1C and 1-hour glucose was evaluated on Independent association of A1C with common carotid artery intima-media thickness (IMT ACC) in individuals with normal glucose tolerance (Standardized β 0.139, p=0.002). In individuals with normal glucose tolerance, A1C was independently associated with carotid intima-media thickness and explained 4.4% of its variation, whereas 1-hour glucose was not informative.
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