Association between Lipid Profile and Ovarian Cancer in women of North India

Objective: The aim of this study was to compare serum lipid profiles: total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c) and very low density lipoprotein cholesterol (VLDL-c) and lipid ratio among ovarian cancer (OC) patients and healthy controls. Methods: Total 300 subjects were enrolled in this study. Study group comprised of 150 clinically and histologically proved cases of ovarian carcinoma and 150 healthy women recruited as a control group. Plasma levels of TC, TG and HDL were determined using a commercially available kit and a semi-automated analyzer. LDL and VLDL were calculated by Friedewald's formula. Results: In our study, we found the higher level of mean serum cholesterol, TGs, LDL-c and VLDL in OC patients as compared to the controls. The HDL level is higher in controls as compared to study group. TGs, HDL-c VLDL were found highly significant in OC patients as compared to controls. The Ratio of TC/HDL, LDL/HDL, HDL/LDL was also found significantly higher in OC patients as compared to controls. Conclusions: The results of the present study shows that plasma lipid levels, except HDL-cholesterol, are increase in OC. As there is an alteration in the plasma lipid profile during gynecologic cancers, it may be helpful for diagnosis of the disease. Further studies needed to investigate, to group important factors including, cancer stages and type of cancer, parity, and menopausal status that may affect lipid profiles in OC patients along with an investigation of new lipid profiles to clarify most lipid factors that may involve in OC development are needed.