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January 1, 1988Thrombosis and HaemostasisOpen Access

Bleeding Time and Platelet Volume in Acute Myocardial Infarction – A 2 Year Follow-Up Study

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Population

34 patients, comprising 18 who had suffered a definite acute myocardial infarction two years prior and 16…

Design

Cohort

Follow-up

2 years

Authors

SKSteen Dalby KristensenInterventional Cardiology PMP C MilnerRoyal Hallamshire Hospital JMJohn F. MartinUniversity of London

Discussion

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Implication

Acute MI platelet changes appear transient; hypothesis-generating without implications for long-term antithrombotic management.

Key Points

Determine whether altered bleeding time and platelet volume distribution observed during acute myocardial infarction persist two years later or predict recurrent clinical events.
Follow-up study conducted two years post-event in 18 patients with verified acute myocardial infarction and 16 chest pain control patients without infarction.
Repeated laboratory evaluations of template bleeding time, platelet count, and platelet volume distribution curves.
Bleeding time significantly lengthened in the myocardial infarction cohort from acute median 169 s to follow-up median 209 s, whereas control bleeding times decreased from median 258 s to 228 s.
Platelet volume distributions in myocardial infarction patients showed a significantly higher percentage of small platelets and lower percentages of medium and large platelets at the acute stage compared to two years later.
Bleeding time correlated negatively with mean platelet volume in patients with ischemic heart disease (n = 26), though baseline platelet parameters did not predict mortality or recurrent infarction.

Structured PICO

Population

34 patients, comprising 18 who had suffered a definite acute myocardial infarction two years prior and 16 control patients who had been admitted with chest pain but no definite myocardial infarction.

Comparator

16 control patients admitted with chest pain but no definite myocardial infarction

Outcome

Bleeding time, platelet count, and platelet volume distributionsurrogate

The shortened bleeding time and altered platelet volume distribution observed during acute myocardial infarction are transient phenomena related to the acute event that reverse after two years.

Cite This Study

Kristensen et al. (1988) studied this question.

synapsesocial.com/papers/6a71a3fea528af2d65c42834 https://doi.org/10.1055/s-0038-1647494

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Bleeding Time and Platelet Volume in Acute Myocardial Infarction – A 2 Year Follow-Up Study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Bleeding Time and Platelet Volume in Acute Myocardial Infarction – A 2 Year Follow-Up Study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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