Why the study?
Do nitric oxide donors (glyceryl trinitrate or S-nitrosoglutathione) reduce platelet activation in patients with acute myocardial infarction and unstable angina treated with aspirin?
Population
60 subjects: 20 patients with acute myocardial infarction and 20 patients with unstable angina, all treated…
Comparison
Infusion of a nitric oxide donor titrated to… vs Baseline measurements and control volunteers…
Design
Cohort
Authors
Loading...
May inhibit platelet activation in AMI/UA despite aspirin; hypothesis-generating for clinical outcomes.
Do nitric oxide donors (glyceryl trinitrate or S-nitrosoglutathione) reduce platelet activation in patients with acute myocardial infarction and unstable angina treated with aspirin?
Nitric oxide donors (glyceryl trinitrate and S-nitrosoglutathione) can inhibit persistent platelet activation in patients with acute myocardial infarction and unstable angina despite aspirin therapy.
Langford et al. (1996) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: