September 1, 1986The Journal of ImmunologyOpen Access

Involvement of natural killer cells in coxsackievirus B3-induced murine myocarditis.

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Population

Adolescent CD-1 male mice inoculated with coxsackievirus B3 (CVB3m)

Comparison

Depletion of natural killer cells via… vs Normal CVB3m-infected mice without NK cell…

Design

Preclinical

Follow-up

3 days postinoculation

Authors

Discussion

Suggests NK cell protection in murine viral myocarditis; leaves open human relevance and therapeutic translation.

Population

Adolescent CD-1 male mice inoculated with coxsackievirus B3 (CVB3m)

Intervention

Depletion of natural killer (NK) cells via intravenous injection of anti-asialo GM1 antiserum

Comparator

Normal CVB3m-infected mice without NK cell depletion

Outcome

Severity of myocarditis, virus titers in heart tissues, and splenic NK cell activitysurrogate

Natural killer cells provide protection against coxsackievirus B3-induced murine myocarditis by limiting viral replication in the heart.

Godeny et al. (1986) studied this question.

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