Activation of cardiac vagal afferents in ischemia and reperfusion. Prostaglandins versus oxygen-derived free radicals.
Population
31 rats (47 chemosensitive vagal afferent fibers located in the left ventricle)
Design
Preclinical
Follow-up
40 minutes (30 minutes occlusion, 10 minutes reperfusion)
Authors
Discussion
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Implication
Increased chemosensitive activity during early ischemia does not yet inform human ACS care; leaves open prostaglandin mediation and translation from rat models.
Structured PICO
P
Population
31 rats (47 chemosensitive vagal afferent fibers located in the left ventricle)
I
Intervention
30 minutes of left anterior descending coronary artery (LAD) occlusion and 10 minutes of subsequent reperfusion, with topical application of H2O2 and intravenous indomethacin (5 mg/kg)
O
Outcome
Activity of vagal fibers (impulses per second)surrogate
In a rat model, early ischemia-induced activation of cardiac vagal afferents is mediated by prostaglandins, whereas reperfusion-induced activation is mediated by oxygen-derived free radicals.
Cite This Study
Ustinova et al. (1994) studied this question.