August 1, 1996Clinical and Experimental Pharmacology and Physiology
Cardiac Vagal Afferent Stimulation by Free Radicals During Ischaemia and Reperfusion
Population
Rats (in vivo model for recording activity from cardiac vagal afferent fibers during ischemia and reperfusion)
Comparison
Topical application of pro-oxidants, 30-min left… vs Resting conditions / baseline
Design
Preclinical
Follow-up
30 min occlusion and subsequent reperfusion
Authors
Discussion
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Member takes
Implication
Suggests distinct mediators of cardiac vagal activation in ischemia versus reperfusion; animal data leave open human translation.
Structured PICO
P
Population
Rats (in vivo model for recording activity from cardiac vagal afferent fibers during ischemia and reperfusion)
I
Intervention
Topical application of pro-oxidants (H2O2, xanthine/xanthine oxidase), 30-min left anterior coronary artery occlusion and reperfusion, and administration of antioxidants (superoxide dismutase, deferoxamine, dimethylthiourea) or indomethacin
C
Comparator
Resting conditions / baseline
O
Outcome
Activity of cardiac vagal afferent fibers (chemosensitive C-fiber endings)surrogate
Cardiac vagal afferent activation is mediated by prostaglandins at the onset of ischemia and by oxygen free radicals during reperfusion in a rat model.
Cite This Study
Schultz et al. (1996) studied this question.