Key result
Blockade of prostaglandin synthesis with indomethacin or sodium meclofenamate significantly decreased the reflex inhibitory responses to coronary occlusion and reperfusion in dogs.
Why the study?
Does blockade of prostaglandin synthesis reduce reflex inhibitory responses during myocardial ischemia and reperfusion in dogs?
Population
alpha-chloralose-anesthetized dogs after sinoaortic baroreceptor denervation (n=15)
Comparison
Prostaglandin synthesis blockade with… vs Vehicle prior to coronary occlusion and…
Design
Preclinical
Authors
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Prostaglandin inhibition attenuates reflex hypotension in inferior ischemia; extends chemosensitive vagal afferent mechanism to reperfusion.
Does blockade of prostaglandin synthesis reduce reflex inhibitory responses during myocardial ischemia and reperfusion in dogs?
This preclinical study demonstrates that prostaglandins are the primary stimulus for chemosensitive ventricular sensory endings that mediate reflex inhibitory responses during myocardial ischemia and reperfusion.
Thames et al. (1989) studied Myocardial ischemia and reperfusion (n=15). Indomethacin or sodium meclofenamate vs. Vehicle was evaluated on Inhibition of renal sympathetic nerve activity and arterial pressure. Blockade of prostaglandin synthesis with indomethacin or sodium meclofenamate significantly decreased the reflex inhibitory responses to coronary occlusion and reperfusion in dogs.